M. Nedim Ince, MD

M. Nedim N. Ince, MD
Assistant Professor
Dept. of Internal Medicine


Dr. Ince's clinical interests include general gastroenterology with particular interest in inflammatory bowel disease. His research focuses on helminthic regulation of intestinal inflammation. His laboratory investigates the role of T helper 2 and TGF-beta signaling pathways in helminthic mucosal immune modulation. His group uses graft vs. host disease and inflammatory bowel disease preclinical models..


Recent Publications

Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells.
Li Y, Guan X, Liu W, Chen HL, Truscott J, Beyatli S, Metwali A, Weiner GJ, Zavazava N, Blumberg RS, Urban JF Jr, Blazar BR, Elliott DE, Ince MN.
J Immunol. 2018 Nov 15;201(10):2910-2922.

STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells.
Li Y, Liu W, Guan X, Truscott J, Creemers JW, Chen HL, Pesu M, El Abiad RG, Karacay B, Urban JF Jr, Elliott DE, Kaplan MH, Blazar BR, Ince MN.
J Immunol. 2018 Nov 1;201(9):2612-2623.

Graft Versus Host Disease After Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management.
Murali AR, Chandra S, Stewart Z, Blazar BR, Farooq U, Ince MN, Dunkelberg J.
Transplantation. 2016 Dec;100(12):2661-2670. Review.

Understanding Luminal Microorganisms and Their Potential Effectiveness in Treating Intestinal Inflammation.
Ince MN, Blazar BR, Edmond MB, Tricot G, Wannemuehler MJ.
Inflamm Bowel Dis. 2016 Jan;22(1):194-201. doi: 10.1097/MIB.0000000000000599. Review.

Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice.
Li Y, Chen HL, Bannick N, Henry M, Holm AN, Metwali A, Urban JF Jr, Rothman PB, Weiner GJ, Blazar BR, Elliott DE, Ince MN.
J Immunol. 2015 Feb 1;194(3):1011-20. doi: 10.4049/jimmunol.1303099. Epub 2014 Dec 19

See a list of publications at PubMed